The U.S. medical technology industry (MTI) is a highly diversified manufacturing sector with significant impacts on health status, quality of life, and the U.S. economy. The industry encompasses the manufacturing of everyday medical devices such as contact lenses and thermometers to such high-tech devices and equipment as transcatheter aortic valves, molecular diagnostics, neuro-stimulators, and state-of-the-art multimodal imaging systems. In this report, The Lewin Group presents estimates of the national impact of the industry, extracted from the most recent business data from the 2012 Economic Census. This report provides updated figures from our previous industry analysis, released in 2010. The industry’s economic impact on each of the 50 states and the District of Columbia will be presented in a subsequent report.